|
KMID : 1035420180060010055
|
|
Journal of The Korean Society of Integrative Medicine
2018 Volume.6 No. 1 p.55 ~ p.62
|
|
|
Association between Periodontitis and Preeclampsia: a Systematic Review
|
|
Ha Jung-Eun
|
|
|
Abstract
|
|
|
Purpose : Preeclampsia(PE) is a pregnancy-specific disease which is characterized by hypertension and proteinuria. This disease occurs in about 2-8% of pregnancies in developing countries and remains among the major causes of maternal and neonatal mortality and morbidity throughout the world. Although the causes of PE are not fully understood, the infection has been considered as the main risk factor for this diseases. Periodontal disease may provide a chronic burden of endotoxin and inflammatory cytokines and the disease has been considered as risk factors of systemic illnesses including cardiovascular disease, atherosclerosis, and cerebrovascular ischemia. So, studies performed over the last 15 years have suggested that periodontal disease may be associated with adverse pregnancy outcomes such as PE. However, this association has not been found in all populations. The aim of this review article was to evaluate whether periodontal status and the presence of specific periodontal pathogens may influence the incidence of PE.
Method : Many research articles searched at the electronic databases(MEDLINE; 2000 to July 2017) including search term as periodontal disease and preeclampsia.
Result : There were 11 case-control studies and 5 cohort studies meeting our inclusion criteria. The results showed that maternal periodontitis (adjusted odds ratio: 1.5 to 9.3) was associated with preeclampsia in 16 epidemiological studies.
Conclusion : It is clear that maternal periodontitis is a risk factor associated with preeclampsia, emphasizing the importance of periodontal care in prenatal programs.
|
|
|
KEYWORD
|
|
|
Periodontal pathogen, Periodonatitis, Preeclampsia, Pregnant women
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|